Keytruda Immunotherapy: How It Works in Cancer Treatment for UPSC

Context: Keytruda Immunotherapy

Keytruda is an immunotherapy drug used in cancer treatment, highlighting a shift towards immune-based cancer care.

What is immunotherapy
• Treatment that activates or strengthens the immune system to fight cancer
• Instead of killing cells directly, it helps the body identify and destroy tumour cells

How it works
• Cancer hides using immune “checkpoints”
• Immunotherapy (like Keytruda) blocks these checkpoints
• This allows T-cells to detect and attack cancer

Types of immunotherapy

  1. Checkpoint inhibitors
    • e.g., Keytruda (PD-1 inhibitor)
  2. CAR-T cell therapy
    • Patient’s T-cells modified to kill cancer
  3. Cancer vaccines
    • Train immune system to recognise tumour proteins

Why important
• More targeted treatment than chemotherapy
• Long-lasting response in some cancers
• Represents shift from destruction → immune activation

PYQ – 2025, Ans – D
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Keytruda Immunotherapy: How It Works in Cancer Treatment for UPSC

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